Aging, Mitochondria, and the Heart - Dr. Antentor Hinton, Jr.

Описание: This week at Journal Club, Dr. Antentor Hinton, Jr., Assistant Professor at Vanderbilt University presents his team's publication "Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging" published in Molecular Psychiatry on 27 September, 2023. The study investigates how aging affects the mitochondrial structure in cardiac muscle, particularly focusing on the loss of cristae morphology and changes in mitochondrial volume.

Link to full article:
https://journals.physiology.org/doi/f...

#journalclub #research #science #mitochondria #biology #vanderbilt #openscience #vincere #cardiac #aging

Dr. Hintons's Profile and Social Media:
Profile: https://medschool.vanderbilt.edu/mpb/...
LinkedIn:   / biogeek26  
Twitter: https://twitter.com/phdgprotein86?lan...

Chapters:

00:00-00:59 Introduction
01:00-12:37 Background
12:38-15:24 Results - Aging Alters Cristae and Mitochondria Morphology in Cardiac Muscle
15:25-17:27 Results - Mitochondrial Size and Mitochondrial Volume are Decreased in Aged Heart Muscle
17:28-18:52 Results - What Mechanism is Causing this Fragmentation in Aged Cardiac Muscle?
18:53-22:31 Results - What Mitochondrial Proteins are Involved in the Aging Process?
22:32-33:30 Results - How is the MICOS Complex Involved in Aging?
33:31-36:35 Results - Decreased Mitochondrial Size, Volume, and Altered Mitochondrial Networks in Gastrocnemius, Soleus, and Cardiac Muscle of Aged Mice in SBF-SEM 3D Reconstruction
36:36-42:55 Results - Mitochondrial Dysfunction in Heart Failure: Modeling and CGCHD6 Genetically-regulated Gene Expression (GREX) in a Medical Biobank
42:56-44:39 Summary and Conclusion
44:40-48:46 Q&A