A Surrogacy Journey with an Unexpected NIPT Result

Описание: 💔 When a False Positive Turns Your World Upside Down
A Surrogacy Journey with an Unexpected NIPT Result

What happens when a PGT-A tested “normal” embryo leads to a high-risk NIPT result?

In this real-life surrogacy case, an Intended Mother shares the emotional rollercoaster of receiving a false positive NIPT result for Trisomy 13, despite transferring a chromosomally screened embryo. Fear, confusion, and heartbreak followed—until diagnostic testing revealed the truth.

This video explains what went wrong, what it means, and what Intended Parents need to know before jumping to conclusions.

🌱 A Hopeful Beginning

The journey started with optimism:
✔ A PGT-A tested euploid embryo
✔ Successful implantation
✔ A smoothly progressing pregnancy

Everything pointed toward a healthy outcome—until a routine screening changed everything.

😟 The Shock: High-Risk NIPT for Trisomy 13

At 14 weeks, the surrogate completed NIPT (Non-Invasive Prenatal Testing).
The result came back high risk for Trisomy 13 (Patau syndrome)—a severe chromosomal condition.

The question every Intended Parent fears:

How could this happen if the embryo was PGT-A tested?

🧬 The Answer: Amniocentesis Reveals the Truth

Knowing that NIPT is a screening test, not a diagnosis, the Intended Mother proceeded with amniocentesis, which analyzes the fetus’s own chromosomes.

✅ Result: Normal fetal karyotype
✅ No Trisomy 13
✅ Anatomy scan showed no abnormalities

What caused the scare? Most likely Confined Placental Mosaicism (CPM)—a condition where the placenta contains abnormal cells, but the fetus does not.

🧠 Key Lessons for Intended Parents

1️⃣ PGT-A, NIPT, and Amniocentesis Are Not the Same
• PGT-A tests a small sample of placental precursor cells
• NIPT analyzes placental DNA in maternal blood
• Amniocentesis tests fetal cells directly

Different tests → different answers.

2️⃣ NIPT Has Limitations—Especially for Trisomy 13
While NIPT is highly accurate for Trisomy 21, its positive predictive value for Trisomy 13 is only ~40%, meaning most positive results are false positives.

3️⃣ Don’t Panic—Confirm Before Making Decisions
A high-risk NIPT result is not a diagnosis.
Always consult a genetic counselor and confirm with CVS or amniocentesis before drawing conclusions.

🤍 Why This Story Matters

This case highlights the emotional vulnerability of Intended Parents—especially in surrogacy journeys where control already feels limited. Knowledge, context, and proper medical guidance can prevent unnecessary fear and life-altering decisions based on incomplete information.

If you’re navigating IVF, surrogacy, PGT-A, or prenatal screening, this story may help you feel less alone—and better prepared.