AUTOMATED BIOCHEMISTRY ANALYSER 😱🤯

Описание: The Roche Cobas Integra 400 Plus is a mid‑throughput, compact bench-top biochemistry analyzer designed for routine to specialized clinical chemistry labs. Here’s a detailed breakdown:


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🔧 Key Features & Specifications

Measurement technologies
Incorporates four methods:

Absorbance photometry (enzymes, substrates)

Turbidimetry (proteins, abuse drugs)

Fluorescence polarimetry (therapeutic drug monitoring, thyroid tests)

Ion‑selective electrode potentiometry (Na⁺, K⁺, Cl⁻, Li⁺)


Throughput & Capacity

Processes up to 400 tests/hour, including ISE

Holds up to 90 primary/secondary tubes and 32 reagent packs (up to 800 tests each)


Open‑tube random access
Continuous loading, automatic STAT priority, barcode scanning for both samples and reagents

Sample & reagent flexibility
Accepts serum, plasma, urine, CSF, hemolysate, whole blood (HbA₁c); sample volumes typically 2–10 µL (ISE uses higher volumes)

*Reagent packs (“cobas c packs”)*
Barcoded, pre-calibrated, refrigerated with 3-month stability—easy swap during runs

Automated quality control
Real-time clot detection, pressure‑based pipetting safeguards, built-in QC and calibration module

Dimensions & infrastructure

Size: ~135 × 66 × 75 cm, ~230–320 kg

Power: 100–125 / 200–240VAC; water: ~2 L/hour




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🧪 Assay Menu & Applications

Broad test menu, supporting 120–140+ assays including enzymes, proteins, electrolytes, therapeutic drug levels, drug abuse, HbA₁c

Ideal for clinical chemistry, TDM, specific proteins, abuse screening, electrolytes, thyroid tests, etc.



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🔁 Real-World Feedback

From labs on Reddit and MedWrench forums:

in biochemistry, (my favourite analyser) the cobas integra400+ the real work horse of the lab! rare maintenance required from my experience.”



However, general sentiment about Cobas:

If you don't have two Cobas analyzers… any maintenance it has to go into standby… daily maintenance can take an hour or more.”



Roche must be treated… like the sugar baby… if you do it will treat you like a king.” (pros & cons)



Bottom line: Reliable and versatile, but demands scheduled maintenance and downtime.


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✅ Pros & Cons

👍 Advantages ⚠️ Considerations

Multifunctional platform – many assays on one unit Requires maintenance downtime; no dual‑online mode
High automation – barcode, automatic clots, reagent handling Standby mode needed for any reagent or hardware change
Broad assay menu, strong QC features Interface dated (Windows‑XP era)
Compact footprint ideal for medium labs Size and weight may require dedicated infrastructure



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📌 Best For

Labs processing 50–250 samples/day or up to ~250,000 tests/year, needing a single analyzer for clinical chem, proteins, TDM, electrolytes, and drug screening. Excellent if you're equipped to manage periodic maintenance and sterilization procedures.

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