Metrino Academy Session #2 "Choosing the righ measurement method : a practical approach."

Описание: METRINO Academy Session #2
Choosing the right measurement method: a practical approach
Recorded online — Feb 5, 2026 (15:00 CET, Paris)
Duration: 1:14:32

Choosing how to measure nanomedicine products is still surprisingly hard, even for experienced teams. Different techniques probe different measurands, sample matrices can completely distort results, and “one correct value” often does not exist unless you define what you are actually measuring.

In METRINO Academy Session #2, Christian Gollwitzer (PTB) and Yuri Antonio Diaz Fernandez (University of Pavia) share a practical, experience-driven approach developed within METRINO, based on interlaboratory work and real case studies. The session introduces decision tables and heat map style guidance to help practitioners select fit for purpose methods for key measurands such as particle size, particle concentration, and chemical composition/homogeneity, including how to handle matrix interference (and when separation tools like AF4 become essential).

This session is designed to be hands-on and discussion-oriented, with live polls and a moderated Q&A.

Speakers
Christian Gollwitzer (PTB, Germany)
Yuri Antonio Diaz Fernandez (University of Pavia, Italy)

Moderation
Alexandre Ceccaldi — ETPN General Secretary, METRINO WP5 lead (Creating Impact)

Key themes covered

Why different methods can give different “size” values (measurand matters)
Measurement uncertainty and compatibility: how to compare results properly
Practical traceability paths, including top-down uncertainty approaches and reference materials
METRINO case studies: hard nanoparticles (FeraSpin R) and liposomes/LNPs
Matrix effects: protein rich media can bias DLS, and AF4 can resolve interference
Chemical homogeneity depends on length scale and sampling volume
Decision tables and heat map style guidance for method selection (size and concentration)

Chapters
00:00:00 Welcome + METRINO Academy format and housekeeping
00:06:13 Metrology 101: what it is and why it matters (Christian Gollwitzer)
00:10:57 Poll 1: methods you use + most important measurand
00:12:17 Case study: silica reference material, “which value is correct?”
00:13:28 Poll 2: find the correct value (tricky question)
00:15:03 Why uncertainty changes the answer (compatibility, error bars)
00:20:08 Poll 3: your practice with measurement uncertainty
00:22:53 METRINO case studies: size, concentration and method comparisons (Yuri Diaz Fernandez)
00:34:52 Decision tables and heat map guidance: method selection for size and concentration
00:37:18 Matrix effects: protein interference and why AF4 helps
00:51:38 Chemical homogeneity: why length scale matters
00:53:01 Q&A opens + Poll 4: biggest challenges right now
00:56:31 Q&A starter: “I need particle size” what do you ask first?
01:10:00 Poll 5: which METRINO decision tools should we publish next?
01:14:20 Closing + next session teaser + survey
01:14:32 End

About METRINO
METRINO (Grant #22HLT04) is funded by the European Partnership on Metrology, co-financed by the European Union’s Horizon Europe programme and participating states. The consortium gathers 20 partners (NMIs, universities, research organisations, pharma, SMEs, hospital) to develop validated measurement methods, SOPs and reference materials for nanotherapeutics to support robust translation to clinic.

Follow METRINO on LinkedIn:   / metrino-project  

More on METRINO: https://metrino.eu

Contact: [email protected]

More on ETPN: https://etp-nanomedicine.eu