The Role of Succinic Acid Dehydrogenase in Mitochondrial Function
Автор: Integrative Medicine Academy
Загружено: 2023-08-15
Просмотров: 1186
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https://MitochondriaMasteryCourse.com
Succinic acid is a central compound of the Krebs cycle (Kc). It sits about halfway between citric acid and oxaloacetic acid and is linked to the enzyme succinic acid dehydrogenase (SDH). This enzyme is critical in mitochondrial function because it directly links the Kc to the electron transport chain (ETC) at complex II. Optimal production of adenosine triphosphate (ATP) occurs when ETC activity is initiated at complex I and II. However, there is more to the story of SDH and problems in its function. For example, elevated succinic occurring from a defect in SDH function is associated with inhibition of hypoxia inducible factor (HIF) degradation. Prolonged HIF activity is seen in angiogenesis, increased cell proliferation, decreased apoptosis, and tumor development. This video, from Kurt N. Woeller, DO of Integrative Medicine Academy, explains some of the functions and clinical considerations of the role of succinic acid dehydrogenase. The information discussed comes from the Mitochondria Mastery Course.
https://mitochondriamasterycourse.com
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