Pt 2 KRAS Lung Cancer Treatment Explained: Options, Co-Mutations & New Hope with Dr. Marcelo Negrao

Описание: Part 2 KRAS PATIENT EDUCATION SEIRES: What’s the current standard of care for KRAS-mutated non-small cell lung cancer? In this episode of the Young Lung Cancer Initiative’s education series, Leah sits down with Dr. Marcelo Negrao, a thoracic oncologist at MD Anderson, to talk about how KRAS-driven lung cancers are treated today and why treatment decisions often depend on more than just the KRAS mutation alone.

Dr. Negrao explains why immunotherapy, often combined with chemotherapy, remains the frontline approach for most patients — and how key biomarkers like PD-L1 expression, disease burden, and co-mutations such as STK11, KEAP1, SMARCA4, and CDKN2A help guide treatment choices. He also breaks down what makes KRAS G12C-targeted therapies like adagrasib (Krazati) and sotorasib (Lumakras) important breakthroughs, while being honest about the challenges they present — from early resistance to variable responses.

If you or a loved one is navigating a KRAS+ diagnosis, this conversation offers insight into how oncologists are personalizing care, what outcomes to expect, and how co-mutations can significantly impact treatment response. We also touch on emerging resistance mutations in EGFR patients, including KRAS G12D and BRAF V600E, and what that might mean at the time of progression.

Whether you're newly diagnosed or looking ahead at next-line options, this episode is full of valuable, up-to-date information that every KRAS patient and caregiver should hear.

Information for requesting an appointment at MD Anderson for self-referring patients:
Phone: 713-792-6110 - option 1.
Website: https://www.mdanderson.org/about-md-a....

#KRAS #LungCancer #KRASG12C #NonSmallCellLungCancer #TargetedTherapies #Adagrasib #Sotorasib #Stage4Cancer #ThoracicOncology #PDL1 #STK11 #SMARCA4 #KEAP1 #CDKN2A #MDAnderson #CancerResearch #YoungLungCancer #YLCI

Chapters
00:00 Introduction to KRAS and Lung Cancer Treatment
02:26 Current Treatment Strategies for KRAS Mutant Lung Cancer
04:45 Emerging Therapies and Their Impact
07:16 Understanding Co-Mutations and Their Role in Treatment
10:09 Future Directions in KRAS Research and Treatment
12:37 Conclusion and Patient Perspectives

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⚠️ Disclaimer
This video is for informational purposes only and is not intended as medical advice. Always consult your healthcare provider for medical concerns or guidance.