Introducing Roche Sequencing by Expansion (SBX) Technology

Описание: Welcome to a new space in NGS with sequencing by expansion (SBX). SBX technology utilizes a proprietary biochemical conversion process to expand and encode the sequence of a DNA template into a surrogate polymer, called an Xpandomer. These molecules are then passed through a high-density complementary metal oxide semiconductor (CMOS)-based sensor module with millions of biological pores, enabling accurate sequencing of hundreds of millions of bases per second. This novel approach aims to deliver speed, flexibility, and scalability so you can expand your sequencing capabilities beyond today’s limits.

00:00 Overcoming sequencing limitations with Xpandomers
00:34 X-NTP structure
01:20 The translocation control element
01:31 X-NTP incorporation
01:56 Threading of Xpandomer through pore
02:35 Measurement of Xpandomer reporters in a highly-parallel manner
02:59 A new paradigm for NGS technology

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