LC-mediated Arousal Elicited by Trigeminal Stimulation Assessment | Protocol Preview

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Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation - a 2 minute Preview of the Experimental Protocol

Maria Paola Tramonti Fantozzi, Tommaso Banfi, Vincenzo De Cicco, Massimo Barresi, Enrico Cataldo, Davide De Cicco, Luca Bruschini, Paola d'Ascanio, Gastone Ciuti, Ugo Faraguna, Diego Manzoni
University of Pisa, Department of Translational Research and of New Surgical and Medical Technologies; Scuola Superiore Sant'Anna, The BioRobotics Institute; Scuola Superiore Sant'Anna, Department of Excellence in Robotics & AI; University of Bordeaux, Institut des Maladie Neurodegeneratives; University of Pisa, Department of Physics; University of Pisa, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine; IRCCS Foundation Stella Maris, Department of Developmental Neuroscience;

To verify whether trigeminal effects on cognitive performance involve locus coeruleus activity, two protocols are presented that aim to evaluate possible correlations between the performance and task-related pupil size changes induced by chewing. These protocols may be applied to conditions in which locus coeruleus contribution is suspected.

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