Share HbA1c: The Hidden Factors - Biological Interferences

Описание: Presented By:
David B. Sacks
John Higgins

Speaker Biography:
David Sacks is Senior Investigator and Chief of Clinical Chemistry Service at the National Institutes of Health, Adjunct Professor of Medicine at Georgetown University, Clinical Professor of Pathology at George Washington University and Honorary Professor of Clinical Laboratory Sciences at the University of Cape Town. He received his medical training at the University of Cape Town. He completed residencies in Internal Medicine at Georgetown University affiliated hospitals in Washington, D.C. and in Clinical Pathology at Washington University, St. Louis. After fellowship training in Clinical Chemistry at Washington University, he spent 21 years in the Department of Pathology at Harvard Medical School.

John Higgins is an Associate Professor of Systems Biology at Harvard Medical School and an Associate Pathologist at Massachusetts General Hospital. His research group located in the MGH Center for Systems Biology uses clinical laboratory and related to data to study the dynamics of human pathophysiologic processes by developing mechanistic mathematical models of complex human disease phenotypes and how they change over time. The group is particularly interested in the population dynamics of circulating blood cells and how these dynamics are perturbed by normal development, inflammation, and chronic disease. The research program integrates medical insight, dynamical systems theory, statistical modeling, and large-scale analysis of medical record databases in pursuit of two goals: (1) advancing fundamental understanding of the dynamics of human pathophysiology, and (2) improving patient diagnosis, monitoring, and treatment. He is also a Board-certified Clinical Pathologist and serves as a Medical Director in the Massachusetts General Hospital Clinical Laboratories, with diagnostic expertise in hemoglobinopathies, disorders of hemostasis and thrombosis, and immune function. He studied biology and bioengineering at Princeton University. Following several years of work as a computer software engineer at the MathWorks, Vermeer Technologies, and Microsoft, he received an MD from Harvard Medical School and an SM from MIT in Health Sciences and Technology, and conducted doctoral research with David Altshuler in human genetics and post-doctoral research with L. Mahadevan in applied mathematics. He completed residency training in Clinical Pathology at Brigham and Women’s Hospital.

Webinar:
HbA1c: The Hidden Factors - Biological Interferences

Webinar Abstract:
HbA1c is routinely used in the clinical laboratory to diagnose and monitor diabetes mellitus. Many methods have been standardized to provide precise and accurate results for normal patients. For the other common Hb variants, most of the methods are now relatively free of analytical interference.



This session explains the clinical value of HbA1c in individual patient care; when an analytically correct result provides clinically misleading information due to red cell/hemoglobin lifespan. Hemoglobinopathies (variants & thalassemia’s), as well as anemia, iron deficiency and genetic variation impact the red blood cell/hemoglobin lifespan and potentially the glycation rate of hemoglobin. How should these patients be identified and managed so the best care can be provided to the patient? How can your laboratory help?



Join us for part 2 of the Sebia webinar series to learn more about the hidden factors – biological interference on HbA1c.

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