Epigenetics| DNA methylation | Histone Modifications| Bisulfite sequencing| Genetics for beginners

Описание: This video lecture explains
1. What is epigenetics?
2. What are different factors and processes affecting epigenetics?
3. What is DNA methylation?
4. How DNA methylation regulates gene expression?
5. What is bisulfite sequencing?
6. What are histones?
7. What is histone modification?
8. How histone modification regulates gene expression?
9. What are the end points of epigenetics?

Image Credit: Wikipedia

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0:00 Epigenetics: Epi+ Genetics Literally means "above" or "on top of" genetics
3:01 DNA methylation, the addition of a methyl group, or a chemical cap, to part of the DNA molecule, which prevents certain genes from being expressed.
7:30 (Without histones, DNA would be too long to fit inside cells.) If histones squeeze DNA tightly, the DNA cannot be "read" by the cell. Modifications that relax the histones can make the DNA accessible to proteins that "read" genes.