REBEL Cast - Is Pip-Tazo Harming Sepsis Patients?
Автор: REBEL EM
Загружено: 2026-02-13
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Описание: In this episode of RebelCast, host Dr. Marco Propersi and guest Dr. Lynnsey Moss discuss the comparative study of piperacillin-tazobactam versus cefepime in the treatment of undifferentiated sepsis. They discuss a recent retrospective cohort study which examines 90-day mortality rates is sepsis patients treated with these antibiotics. The researchers explore the role of anti-anaerobic coverage and its potential for disrupting the gut microbiome. Key points discussed include the method of instrumental variable analysis, the validity of study findings, and a comparison with the ACORN trial. The episode concludes with a cautious stance on changing clinical practice based on these findings. 00:00 Introduction and Welcome 00:14 Meet Lindsey Moss 00:37 Discussion on Piptazo vs Cefepime 01:55 Research Background and ACORN Trial 03:03 Study Methodology 05:20 Study Results and Analysis 08:52 Instrumental Variable Analysis Explained 12:11 Critical Evaluation of the Study 17:44 Conclusion and Takeaways 18:36 Closing Remarks
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