Antibiotic Therapy for PJI & FRI I Dr. Neha Gupta

Описание: Antibiotic Therapy After DAIR in Prosthetic Joint & Fracture-Related Infections

In this expert session, Dr. Neha Gupta, Infectious Diseases Specialist and Founder of NG Swasta, discusses principles of antibiotic therapy following Debridement, Antibiotics, and Implant Retention (DAIR) in Prosthetic Joint Infection (PJI) and Fracture-Related Infection (FRI).

This talk, delivered at the 25th Congress of the Asia-Pacific Orthopedic Association, highlights the critical role of biofilm, rational antibiotic selection, bone penetration, antibiobiofilm agents, host factors, and multidisciplinary collaboration between orthopedics and infectious disease specialists.

Key learning points include:

1 Pathogenesis and stages of biofilm in PJI & FRI

2 Antibiotic selection based on organism, PK/PD, and bone penetration

3 Gram-positive vs Gram-negative infections (Indian perspective)

4 Role of rifampicin, fluoroquinolones, TMP-SMX, linezolid, daptomycin

5 Managing MDR organisms and treatment failures

6 Importance of early ID consultation for better outcomes

📌 This session is intended for orthopedic surgeons, residents, and infection specialists.

prosthetic joint infection
fracture related infection
DAIR procedure
antibiotic therapy PJI
biofilm infection orthopedics
orthopedic infection management
infectious disease orthopedics
PJI antibiotic guidelines
FRI management
bone and joint infections
MRSA prosthetic joint infection
gram negative orthopedic infection
rifampicin biofilm
antibiotic bone penetration
DAIR infection treatment
orthopedic conference lecture
Asia Pacific Orthopedic Association
medical education orthopedics

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00:00 Introduction & Conference Context
00:34 Disclaimer & Importance of Early ID Consultation
00:54 Biofilm Pathogenesis in PJI & FRI
01:46 Why Biofilm Makes Infections Difficult to Treat
02:26 Source Control vs Implant Retention
02:36 Principles of Rational Antibiotic Selection
03:09 Gram-Positive vs Gram-Negative Organisms
03:42 PK/PD & Bone Penetration of Antibiotics
04:16 Antibiotics with Anti-Biofilm Activity
04:34 Mono vs Polymicrobial Infections – Case Example
05:02 Toxicity & Safety Considerations
06:00 Host Factors & Dose Adjustments
06:35 Indian Microbial Epidemiology
07:00 MDR Pseudomonas Case Discussion
08:23 Modern Combination Therapy Options
08:37 Antibiotics with Good Bone Penetration
09:05 MRSA Prosthetic Joint Infection Case
10:16 Individualized Therapy & Drug Tolerance
10:49 Multidisciplinary Team Approach
11:01 Conclusion & Key Takeaway