EXTRINSIC PATHWAY OF APOPTOSIS (Part-4) | CSIR NET | GATE | M.Sc. | B.Sc.

Описание: TOPIC OF DISCUSSION: EXTRINSIC PATHWAY OF APOPTOSIS (Part-4) for CSIR NET

The extrinsic pathway triggers apoptosis in response to external stimuli, namely by ligand binding at ‘death’ receptors on the cell surface.
These receptors are typically members of the Tumour Necrosis Factor Receptor (TNFR) gene family, such as TNFR1 or FAS. Binding at these receptors leads to receptor molecules grouping up on the cell surface to initiate downstream caspase activation.
The extrinsic pathway is initiated by the activation of caspase-8 or -10. Caspases-8 and -10 are activated through another caspase-activating platform: DISC (Death Inducing Signaling Complex) consisting of the death receptor, the adaptor protein FADD, and caspase-8 (or -10)

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