T Cells Unlock PRRSV Vaccine Success: Protecting Pigs from Deadly Virus
Автор: Boundless Explorations
Загружено: 2025-11-29
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Discover how T cells drive vaccine effectiveness against porcine reproductive and respiratory syndrome virus (PRRSV) in pigs.
A groundbreaking study reveals that current PRRSV vaccines work through T cell responses rather than antibodies, despite the virus's rapid mutations.
PRRSV causes billions in losses to the pork industry annually. Vaccinated pigs struggle with broadly neutralizing antibodies due to the virus's fast mutation rate.
Learn about the immune system's role: antibodies tag pathogens, while T cells eliminate infected cells and aid memory.
Research by Michael Rahe and team at North Carolina State University and Iowa State University analyzed pig groups with different vaccination scenarios.
Findings show elevated PRRSV-specific T cell responses in vaccinated pigs, leading to reduced virus levels in blood and lungs, even without matching antibodies.
This highlights conserved virus parts that vaccines target. Future vaccines could be more effective by focusing on T cell activation.
Published in Vaccine, this study paves the way for better porcine health strategies.
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