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The Genetics of Acute Myeloid Leukemia (AML)

Автор: The Leukemia & Lymphoma Society of Canada

Загружено: 2022-06-07

Просмотров: 7711

Описание: In acute myeloid leukemia (AML), something goes wrong with the DNA of the bone marrow cells causing normal bone marrow cells to become leukemia cells. DNA is the material that carries all the information about how our bodies look and function; each piece of information is carried on a different section of DNA - and these sections are called genes. Genes tell a cell how to make a specific protein which is u sed by the cell to grow and survive. DNA is organized into tightly coiled bundles called chromosomes, that contain thousands of genes. We have 23 pairs of chromosomes.

AML is classified into several broad subtypes based on cell features and genetics. People with AML could have damage in a gene's DNA sequence called a genetic mutation. Or they could have damage to part of a chromosome. In most cases, we don't know why DNA damage happens and there is no way to prevent it. But we do know that you can't give it to somebody or catch it from somebody.

In acute promyelocytic leukemia (APL), genetic damage causes parts of chromosomes 15 and 17 to switch places with each other. This exchange is called translocation.

For more information about AML, visit:
https://www.bloodcancers.ca/i-have-bl...

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The Genetics of Acute Myeloid Leukemia (AML)

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