Histone methylation | Part 5 | HKMTs and HDMs | Epigenetics

Описание: HKMTs
➢SET domain containing HKMTs (SET1-H3K4me and SET2-H3K36me)
➢EZH2- H3K27me
➢Suv39h1/h2, SETDB1, G9a- H3K9me1, 2, 3
➢MLL- H3K4me
Mixed lineage leukemia (MLL1)
➢DOT1L- H3K79me –only non-SET domain containing HKMT

Histone demethylases are enzymes that remove methyl groups from histones, counteracting the effects of histone methyltransferases (HKMTs) and providing a dynamic mechanism for epigenetic regulation.