Immunology and Cancer 3: Immune Checkpoints: Biology and Therapeutic Strategies (from PDB-101)

Описание: This three-part series explores the human immune response to cancer focusing on cellular and molecular details of the process. Part 1 showcases the process of antigen harvesting by dendritic cells and later the T-cell maturation process. Part 2 focuses on T-cell activation and demonstrates the mechanisms by which the immune system destroys the cancer cells. Part 3 focuses on the immune checkpoints - a mechanism by which the immune system terminates the immune response and later describes the immune checkpoint therapies used in cancer treatment.

Video Guide
0:05 Introduction to immune checkpoints
0:17 Secondary signal inhibition at the dendritic cell/T-cell synapse
0:58 Primary signal inhibition in Killer T-cells by PD-1/PDL-1 interaction
1:50 Tumor formation and metastasis
2:03 Introduction to immune checkpoints therapies and monoclonal antibodies
2:21 Restoration of the secondary signal at the dendritic cell/T-cell synapse by monoclonal antibodies
2:34 Restoration of Killer T-cell action by monoclonal antibodies
2:45 Monoclonal antibody cocktails

Video Credits
Story by
Ethan Cartagena (Spring 2022 RCSB PDB Intern)

Story Support
Steven C. Almo (Albert Einstein College of Medicine), Stephen K. Burley (RCSB PDB), Paul Craig (RIT), David Goodsell (RCSB PDB), and Maria Voigt (RCSB PDB)

Animation and Video Editing
Maria Voigt (RCSB PDB)

Narration
Emma Chavez (Summer 2022 RCSB PDB Intern)

Sounds
Pixabay.com

Learn more about the molecular biology of Cancer on PDB-101: https://pdb101.rcsb.org/browse/cancer

This video features experimental structures from the Protein Data Bank along with Computed Structure Models from the AlphaFold DB. Visit rcsb.org to explore these structures in 3D.
MHC class I: 1HSA, AF_AFP01889F1
T-cell Receptor: 1TCR, 2HAC
CD8 Co-receptor: 1AKJ, AF_AFP01732F1
B7/CTLA-4 Complex: 1I8L, 1I85
B7: AF_AFP42081F1
CTLA-4: AF_AFP16410F1
Monoclonal Antibody/MHC class I Antigen Complex: 3UO1
PD-1 in Complex with Monoclonal Antibody: 5GGS
PD1: AF_AFQ15116F1
PD-1/PD-L1 Complex: 3BIK
PD-L1: AF_AFQ9NZQ7F1
Immunoglobulin: 1IGT