Lecture 9: Likelihood and Linkage Analysis in Human Pedigrees
Автор: Professor David Gresham
Загружено: 2025-09-30
Просмотров: 33
Описание:
(0:00) Intro
(0:08) Lecture Overview
(0:46) Recombination Fraction Work Problem Example
(5:56) Gene Mapping in Humans
(8:08) Disease Genes Locations
(13:18) Cosegregation of SSRs
(14:02) Genetic Linkage Mapping Article
(15:09) Example of a Genetic Linkage Map (1987)
(17:58) Pedigree - Finding Evidence of Linkage Work Example
(28:24) Log of Likelihood
(29:37) Pedigree Work Example 2
(38:18) Likelihood of Recombinants in Progeny
(40:48) How to Detect Linkage in Humans
(51:21) LOD Score
(52:36) How to Detect Linkage in Humans Continued
(53:00) Utility of LOD Scores
(54:33) Review of Lecture Material
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