Psychedelics and Related Plasticity - Promoting Neurotherapeutics

Описание: The CEO of Emery Pharma introduces Professor David Olson, who has expertise in chemistry, neuroscience, and neuropharmacology. Professor Olson's research focuses on developing treatments for stress-related neuropsychiatric diseases, such as depression, post-traumatic stress disorder, and substance use disorder. He explores the use of psychoplastogens, small molecules that promote structural neuroplasticity in the brain. One well-known psychoplastogen is ketamine, which has shown promising effects in regrowing dendritic spines and restoring synaptic connectivity. However, ketamine lacks circuit-level selectivity. Professor Olson's lab investigates the serotonin receptor 5-HT2A as a target for modulating neuronal structure. Classic serotonergic psychedelics like LSD and psilocybin have been found to promote dendritic arbor complexity and spine growth in cortical neurons. The effects of psychedelics on neuronal structure are long-lasting, with even short stimulation periods producing sustained changes. Studies have shown that psychedelics like psilocybin can increase dendritic spine density for at least a month. These compounds have shown potential for treating various neuropsychiatric disorders and are believed to target the prefrontal cortex, a critical brain region.

About Emery Pharma:
Emery Pharma is a full-service contract research laboratory, supporting the end-to-end development of small molecule drugs, biologics, biosimilars, gene therapy, botanicals, and more.

Emery Pharma's premium services include analytical, bioanalytical solutions, microbiology & cell biology services, drug and impurity characterization, and general R&D and cGMP/GLP support.

At Emery Pharma, our focus is to find innovative solutions for our Clients’ toughest challenges and tailoring those solutions to fit each Client’s unique needs. Our experienced scientific team will manage the process: from drug discovery, proof-of-concept, data management, data analysis, to gathering insights. The team excels at solving scientific challenges, and addressing any issues early in the process, so Clients don’t experience unnecessary setbacks.

Emery Pharma’s experienced chemists and biologists deploy state-of-the-art technology. Instrumentation ranges from high-resolution mass spec (Orbitrap), Triple quad LC-MS/MS, GC-MS, Preparative HPLC, and 400 MHz multinuclear NMR.

Contact us: [email protected]
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keyword:
Professor David E. Olsen
Chemistry
Neurosciences
Stanford University
Stanley Center for Psychiatric Research
Broad Institute of MIT and Harvard
Academic Lab
UC Davis
Psychedelic
Neuroplasticity
Cortex
Psychoplastogen
Small molecule
Ketamine
Neuronal structure
Single dose
Non-hallucinogenic psychoplastogen
Therapeutic effect
Central nervous system
Medicinal Chemistry
Molecular cellular neurobiology
Behavioral neuropharmacology
Associate editor
ACS Chemical Neuroscience
Award
Geordie False Pie Award
Sigma Kai Young Investigator Award
Life Young Investigator Awards
Sacramento Business Journals 40 Under 40
UC Davis Institute for Psychedelic and Neurotherapeutics
Alzheimer's
Dementia
Jeffy Award
UC Davis Department of Chemistry
Grant
Research application
Chemistry biology and neurology
CNS diseases
Dr. Olson
Research
Brain disorders
Stress-related Neuropsychiatric diseases
Depression
Post-traumatic stress disorder
Substance use disorder
Prefrontal cortex
Chemical imbalances
Selective serotonin tone and reuptake inhibitors
Psychoplastogens
Cycloplastogens
Dendrites
Dendritic spines
Excitatory synapses
Ketamine-like effects
Neuronal structure
5-HT2A receptor
Serotonergic psychedelics
LSD
Silacin
Morphology
Structural plasticity
Shoal analysis
Radii
Crossings
Neuronal growth
Dimethyltryptamine (DMT)
In Vivo
Golgi staining
Electrophysiology
Trans-diagnostic
Panacea-like
Prefrontal cortex circuits
Antidepressant-like effects
Genetic knockout models
Depression
Anhedonia
Sucrose preference test

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