Formulation Selection and in-vitro Screening for Oral Bioavailability Enhancement
Автор: Capsugel
Загружено: 2017-10-20
Просмотров: 2295
Описание:
Oral administration of small molecules has become increasingly difficult due to a significant portion of new candidates demonstrating poor aqueous solubility. Drug developers must evaluate many enabling technologies to reach targeted exposure levels. Selecting the proper technology to improve oral bioavailability can be complex, and a series of steps should be taken early in development to ensure that the most appropriate technology is selected.
In this webcast, participants will learn about an approach for selecting the optimal, phase-appropriate technology, from compound onboarding to drug intermediate and dosage form manufacture. Specific topics include in-silico predictions based on drug physicochemical characterization, problem statement definition with respect to absorption in the intestinal tract, and in-vitro tests for evaluating enabled formulations.
Michael Grass
Senior Research Chemist
Capsugel Bend (Capsugel – now a Lonza company )
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