177Lu-PSMA-617 in metastatic castration-resistant prostate cancer shows higher PSA response with...
Автор: ecancer
Загружено: 2026-02-05
Просмотров: 2
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Dr Kim Nguyen Chi speaks to ecancer about the CCTG PR.21 phase II randomised trial that directly compares 177Lu-PSMA-617 (LU-P), a radioligand therapy targeting PSMA, with docetaxel (DOC) chemotherapy in chemotherapy-naïve patients.
The study found that while radiographic progression-free survival was similar, 177Lu-PSMA-617 demonstrated superior PSA response and lower toxicity, suggesting a meaningful role in preserving quality of life.
However Dr Chi highlights that overall survival favoured docetaxel, highlighting a potential trade-off between disease control and long-term outcomes.
He concludes by saying that these data support the need for personalised treatment approaches in mCRPC based on patient goals, disease biology, and tolerance.
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