What Are Prion Diseases| Causes of Prion (PrPSc) |Prion Relationship to Alzheimer’s & Parkinson’s

Описание: Prion diseases are a group of neurodegenerative disorders .Recognizable among the animals are Bovine Spongiform Encephalopathy(BSE) in cattle ,Chronic Wasting disease(CWD) in deer, Creutzfeldt-Jakob disease(CJD)in humans.
Prion causes the brain tissues appear like a sponge, rare in humans and include sporadic misfolding of PrP.
The cause of Prion disease is the prion protein (PrPC)misfolding into (PrPSc) pathogenic conformation .The PrPSc aggregate in the CNS resulting to an increase in (β)-sheet secondary structure. But, the exact mechanism of misfolding is unknown.
Prion properties are similar to Alzheimer's and Parkinson's disease. These diseases too are neurodegenerative disorders linked to misfolding of a host-encoded protein in the CNS. Like Prion, Alzheimer's and Parkinson's affect people of 65 years and older.
Like, Prion these diseases can be either sporadic or linked to a genetic mutation increasing the propensity of the protein to misfold.
Aβ and α-syn are hypothesized to propagate via the same self-templating conversion mechanism as PrP. Similarities among these diseases have potential importance in drug development.