Sciatic Nerve Constriction and Pain Hyersensitivity Testing

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Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats - a 2 minute Preview of the Experimental Protocol

Paul J. Austin, Ann Wu, Gila Moalem-Taylor
University of New South Wales , School of Medical Sciences;

Due to the simplicity of surgery and the robust behavioural outcome, chronic constriction of the sciatic nerve is one of the pre-eminent animal models of neuropathic pain. Within 24 hrs following surgery, pain hypersensitivity is established and can be quantitatively measured using a von Frey aesthesiometer (mechanical test) and plantar analgesia meter (thermal test).

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