Levinthal's Paradox, Protein Folding and AlphaFold

Описание: Around five decades ago, Cyrus Levinthal, an American molecular biologist, postulated that if a protein were to sample every possible conformation of its amino acids, it would take longer than the age of the universe to assemble into its three-dimensional shape. Although scientists had been studying proteins for decades prior, the mystery of how proteins could reliably fold into their conformations on a millisecond scale had remained unanswered. In the many years since studies of protein folding began, the question of how proteins fold has been slowly unraveling, and today, it is possible to predict proteins’ structures based on the amino acid sequences. Recently, artificial intelligence has been able to quickly and accurately determine the conformation of proteins from their amino acid sequence, which will enable tremendous advancements in microbiology and further our understanding and application of proteins for medicine.

Transcript:
https://docs.google.com/document/d/1F...

Music by Emile van Krieken:
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Song: Wings (Aether 2)
   • Emile van Krieken - Wings (Aether 2)  

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