Telomere Replication | Telomere Synthesis | CSIR NET DEC 2025 | TNS CONCEPTS APP | NILESH SONI

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Important Notes:
The telomeres, or ends of eukaryotic chromosomes, are composed of repeats of short, GC-rich sequences.
The exact sequence of the repeat in a telomere is species-specific. Telomerase is a remarkable enzyme that includes multiple protein subunits and an RNA component.
Telomerase acts to extend the 3’ end of its DNA substrate.
Telomerase does not need an exogenous DNA template to direct the addition of new dNTPs.

As a result of this unusual mechanism, the newly synthesized DNA is single-stranded.

The key to telomerase’s unusual functions is revealed by the RNA component of the enzyme, called “telomerase RNA” (TER).
Depending on the organism, TER varies in size from 150 to 1300 bases.



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