HLA Typing Explained: IVF Fails in a Perfect Embryo| Dr Jay Mehta, Mumbai | Reproductive Immunology

Описание: Hi everyone, I’m Dr. Jay Mehta from Shree IVF Clinic!
If you've been dealing with recurrent miscarriages or failed IVF implantations, one of the tests your fertility specialist might suggest is the HLA typing test. This test often raises many questions, especially because of its use in transplant medicine.
____________________________
If this video helped you understand embryo grading better, please like and subscribe for more IVF insights.
Have questions or want personalized guidance?
Visit our website at https://www.shreeivfclinic.com/dr-jay... and reach out to us.
Don’t forget to leave your questions in the comments I’m here to help!
_____________________________
Video Flow
0:00 Introduction
0:14 Why HLA typing is done in recurrent implantation failure or abortions
0:30 Use of HLA typing in transplant vs. fertility medicine
0:41 Importance of mismatch between partners in reproductive immunology
1:07 Sample report cost, duration, and blood sample requirement
1:36 What is HLA-C and HLA-G’s role in implantation
2:14 Why partner similarity can cause implantation issues
2:54 Breakdown of a sample HLA report with allele matching
3:51 Matching percentage calculation method
4:34 Difference in alleles across partners in the sample report
5:34 Meaning of over 50% similarity and high miscarriage risk
6:04 When HLA typing holds diagnostic value
6:56 What happens when similarity is 50% or more
7:22 Role of immunosuppressants like tacrolimus, IVIG, and donor gametes
8:01 Final thoughts on interpreting the report correctly
_____________________________
HLA Typing Explained: Why IVF Fails Even with Perfect Embryo? | Dr Jay Mehta, Mumbai

What is HLA Typing?
HLA typing stands for Human Leukocyte Antigen typing. It’s a genetic test commonly used by transplant physicians to determine compatibility between a donor and a recipient. The goal in transplant medicine is to find the closest HLA match so the recipient’s immune system doesn’t reject the transplanted organ. The higher the match between HLA alleles, the better the chances of acceptance.

Why Is It Done in Fertility Treatments?
When couples face repeated implantation failure or recurrent pregnancy loss, fertility experts suspect there might be an immunological cause. One of those causes is excessive HLA similarity between partners. In fertility, too much similarity between a male and female partner's HLA alleles can lead to the maternal immune system failing to recognize the embryo as a semi-foreign body. As a result, it doesn't mount the protective immune response needed to support the pregnancy.

What to Look for in a Report!
In the sample report, you’ll see HLA alleles listed for both partners. Let's say each partner has 6 alleles across different loci — that's a total of 12. A report might say 3 out of 12 alleles match. That means a 25% match.

Key Risk Factors Based on Report
If both partners carry HLA-C2 type alleles (C2/C2 combination), it increases pregnancy loss risk. Similarly, if the report shows over 50% HLA allele matching, the immune system may fail to respond appropriately to the embryo, increasing the chance of rejection.

Does a Low-Match Report Guarantee a Healthy Pregnancy?
No. This test does not provide a guarantee. A low match only reduces one possible risk factor. For this report to be relevant, the couple must fulfill three important conditions:
They must have a normal karyotype (genetic testing must be clear for both).

The embryos transferred should be chromosomally normal (euploid).
There should be no other anatomical or hormonal abnormalities.
Without fulfilling these conditions, HLA typing won’t help in drawing meaningful conclusions.

Is HLA Typing Always Necessary?
No. It is only advised when:
There’s repeated unexplained IVF failure with good-quality embryos.
_____________________________
Related Videos:
1. क्या Infertility आपको नामर्द बनाती है? | Zero Sperm Count: Does It Make You Less of a Man? | Dr Jay
   • क्या Infertility आपको नामर्द बनाती है? | Z...  

2. What Is a Good Embryo? IVF Grading Explained Step-by-Step! | Dr Jay Mehta, Mumbai
   • What Is a Good Embryo? IVF Grading Explain...  

3. Recent advances in Endometriosis and Adenomyosis | Dr Jay Mehta - Shree IVF Clinic
   • Recent advances in Endometriosis and Adeno...  
----------------------------------------------------------
About Dr Jay Mehta & Shree IVF Clinic

Dr Jay Mehta is the Scientific Director of Shree IVF Clinic, a Luxury Facility for Advanced Assisted Reproduction and Advanced Pelvic Surgery in Mumbai. He is a very well-known Fertility Specialist and is one of the few specialists in the country who is also an extremely sound Embryologist and Andrologist.

For Online or Clinical Appointments, call us at +917738155558

#IVF #FailedIVF #RecurrentMiscarriage #ImplantationFailure #FertilityTreatment #FertilityTesting #FertilitySpecialist #HLATyping #GeneticTesting #Fertility #Infertility #DrJayMehta