Late Effects after a Transplant Using Donor Cells (Allogeneic Transplant) 2021

Описание: Summary: Learn about medical complications that can develop months or years after a transplant using donor bone marrow, stem cells or cord blood. Learn how you can minimize the risk of developing problems and get appropriate treatment if a complication occurs.

Presenter: Catherine Lee MD, Assistant Professor of Medicine in Division of Hematology/BMT, Huntsman Cancer Institute, University of Utah Health. Meet Dr Lee: https://sociology.rutgers.edu/faculty...

To read the transcript, go to: https://www.bmtinfonet.org/video/late...

Highlights:

Late effects may arise from pre-transplant exposures, cancer treatment itself, graft-versus-host disease, or a patient’s inherent risk factors.
-Transplant survivors have about triple the risk of developing secondary cancers that can affect many different parts of the body.
Fatigue is the most common late effect among survivors, and it can arise from many causes. Interventions include exercise, improved sleep, treating pain, and cognitive and behavioral therapy.

Presented at the 2021 Celebrating Life a Second Chance at Life Virtual Symposium, April 17-23, 2021
Presentation is 32 minutes long with 20 minutes of Q & A.

Key Points:

(04:07) “Long term” effects begin during treatment whereas “late effects” were absent or not clinically obvious during treatment but appear thereafter.

(05:26) Late effects can impact physical, emotional and spiritual health and have a significant impact on a survivor’s overall well-being.

(08:31) Damaged DNA. and prolonged inflammation, and immune dysfunction can all be triggers for late effects.

10:55) Transplant survivors have an increased risk of cardiac effects like coronary artery disease and cardiomyopathy.

(13:23) Secondary cancers can affect the skin, thyroid, mouth, neck, breast, cervix, and esophagus.

(14:59) There are screening recommendations for each of these cancers that may lead to early detection and treatment.

(18:25) Bone disorders may arise from steroids and radiation. Interventions include bone scans, weight-bearing exercises, and monitoring calcium and vitamin D levels.

(25:22) Neurocognitive changes such as memory loss often appear posttransplant but can improve and return to normal within one to five years after transplant.

(27:47) Additional late effects may affect the eyes, mouth, kidneys, or liver. Peripheral neuropathy is also a very common late effect of chemotherapy and radiation.

(29:39) High quality survivorship may require multiple specialists. Patients should know their treatment risks and be pro-active in addressing them.

Meet the speaker: https://sociology.rutgers.edu/faculty...

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