Game Changer: New Peptide REVERSES CRC Immune Evasion!
Автор: Sonia Rao
Загружено: 2026-01-06
Просмотров: 1
Описание:
Discover a groundbreaking new mechanism in colorectal cancer (CRC) immune evasion and a promising peptide, APC11, that could revolutionize treatment for even ICB-refractory cases! This video dives deep into a critical breakthrough, moving beyond traditional Wnt/beta-catenin pathways to reveal a significant beta-catenin-independent immune escape strategy. We explore how APC loss orchestrates anomalous cell immune evasion by increasing PTPN13 activity, which then dephosphorylates STAT1. This dampens critical immune responses, leading to impaired MHC class I antigen presentation and preventing effective CD8+ T cell recognition. Learn how the novel APC11 peptide intervenes by blocking the PTPN13-STAT1 interaction, restoring STAT1 phosphorylation, enhancing immune signaling, and facilitating robust CD8+ T cell infiltration. We discuss compelling pre-clinical data showing APC11's ability to inhibit cellular progression and amplify the efficacy of programmed cell death 1 (PD-1) blockade, offering a potential game-changing combinatorial strategy for CRC.
#ColorectalCancer #CancerResearch #Immunotherapy #Peptides #DrugDiscovery
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