G. Ilziibat - Assessment of FMD vaccines in Mongolia and the role of Bactrian camels

Описание: G. Ilziibat - Assessment of FMD vaccines in Mongolia and the role of Bactrian camels

Session: Vaccine performance

Open Session of the EuFMD – 2018 – Increasing Global Security in the supply of effective vaccines – 29-31 October 2018 -Borgo Egnazia, Italy

Introduction
Since early 2017, an upsurge of FMD cases were seen in Mongolia with both O-Ind-2001 and O PanAsia lineages having been detected. Vaccination and a modified stamping out policy has been applied in addition to other control measures. This study presents data from these outbreaks including incidence data in different species and the results of a small-scale post vaccination immunogenicity study.

Material and methods
Government surveillance data was used to estimating the disease incidence in different species. Sampling protocols for evaluating immunogenicity were as described in the FAO-OIE Post Vaccination Monitoring (PVM) guidelines. Comparisons were made between cattle, sheep and camels, with oil and aqueous adjuvant vaccines and one or two dose primary courses. Virus neutralisation tests were performed using priority field strains from the region including O Mya-98, O Ind-2001, O PanAsia and A Sea-97. Data were analysed using multivariate interval regression.

Results
Between January 2017 and April 2018, outbreaks were reported in cattle, sheep, goats and camels in 9 different provinces affecting 1,277 herders. During this time, the province level incidence in different species ranged from 0.02-2.3% in cattle, 0-0.17% in sheep, 0-0.07% in goats and 0-1.7% in Bactrian camels. From the latter, virus has been successfully isolated and is awaiting sequencing. The PVM studies revealed higher titres in response to oil based vaccines for all strains. Although similar in cattle and sheep, in camels titres were significantly lower. Significantly higher titres were seen with a two dose primary course.

Discussion
This study gives an overview of the FMD outbreaks in Mongolia and highlights the role of Bactrian camels. This PVM study indicates an oil-based vaccine with a two dose primary course gives maximum titres although further studies are needed to optimise the dose in Bactrian camels.

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