Buspirone (Buspar) for ADHD?

Описание: Main Chapters:
00:00 Intro - Buspirone for ADHD?
00:13 Take home message
01:24 What is Buspar? (Buspirone)
10:12 Buspirone Treatment Uses
12:13 Buspirone for Treating ADHD?
16:11 Gepirone (Exxua)

The FDA approved Buspar for anxiety in 1986, and it has been available as a generic busprione since 2001. Pharmacologists classify buspirone as a serotonin 1A partial agonist, as its primary action appears to be the activation of pre-synaptic serotonin receptors, which gradually decreases firing of serotonin neurons.

For years, buspirone has been considered a third or fourth tier option for treating ADHD. In addition to effectively treating anxiety associated with ADHD, it may also provide direct benefit for ADHD. 1-2-pyrimidinylpiperazine (1-PP), a major metabolite of buspirone, is an alpha-2 antagonist, which boosts levels of norepinephrine, dopamine and serotonin. Limited research indicates buspirone does reduce ADHD symptoms in humans.

A handful of studies, almost all in rodents, indicate that buspirone can successfully treat several side effects associated with Ritalin, including teeth grinding (bruxism), liver toxicity, and growth inhibition. Buspirone also appears to reduce the potential for substance abuse and cognitive dulling that are associated with long term Ritalin use in rodents.

In September 2023, the FDA approved gepirone, (Exxua) which is chemically similar to buspirone, for the treatment of depression. Gepirone is also metabolized to 1-PP, so you may well be hearing more about this class of drugs for depression, anxiety, and ADHD.

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References:
Buspirone in ADHD (1998)
https://www.jaacap.org/article/S0890-...

Azapirones for Attention Deficit Hyperactivity Disorder: A Systematic Review (2016)
https://www.thieme-connect.com/produc...

Buspirone versus Methylphenidate in the Treatment of Children with Attention- Deficit/ Hyperactivity Disorder: Randomized Double-Blind Study
https://acta.tums.ac.ir/index.php/act...

Buspirone Versus Methylphenidate in the Treatment of Attention Deficit Hyperactivity Disorder: A Double-Blind and Randomized Trial (2010)
https://link.springer.com/article/10....

Co-treatment with low doses of buspirone prevents rewarding effects of methylphenidate and upregulates expression of 5-HT1A receptor mRNA in the nucleus accumbens (2021)
https://www.sciencedirect.com/science...

Full Chapter list:
00:00 Intro - Buspirone for ADHD?
00:13 Take home message
01:24 What is Buspar? (Buspirone)
03:12 Approval and Usage of Buspar
04:12 Potential Side Effects of Buspar
04:53 Buspirone Half-life and Dosage
06:36 Buspirone and Metabolites
06:54 1-(2-Pyrimidinyl) Piperazine (1-PP)
07:51 6-Hydroxybuspirone
08:17 Buspirone and Dopamine
09:25 Buspirone and Liver Enzymes
10:12 Buspirone Treatment Uses
12:13 Buspirone for Treating ADHD?
13:21 Buspirone and Stimulants
16:11 Gepirone (Exxua)
17:05 Outro

Streamed live January 17, 2024

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Psychiatrist, neuroscientist, and author John Kruse, MD, PhD presents practical, actionable, well-researched information about treatment options that scientists and clinicians recommend for adult ADHD and other mental health conditions.
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