Tigecycline; Chemical name, Molecular Formula, Molar mass, Chemical Structure
Автор: Sokoto Pharmacology
Загружено: 2026-02-16
Просмотров: 1
Описание:
🔬 Chemical Details
Chemical name (IUPAC):
(4S,4aS,5aR,12aS)-9-
\[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-1,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboxamide
Molecular formula:
C₂₉H₃₉N₅O₈
Molar mass:
≈ 585.65 g/mol
Chemical structure (description):
Tigecycline is a glycylcycline antibiotic, structurally related to tetracyclines but with key modifications:
A tetracyclic fused ring system typical of tetracyclines.
A dimethylamino group at position 4, essential for ribosomal binding.
Multiple hydroxyl groups and carbonyl groups that enhance polarity and hydrogen bonding.
A carboxamide substituent at position 2.
A unique tert-butylglycylamido side chain at position 9, which differentiates Tigecycline from older tetracyclines and confers activity against resistant bacteria.
Several stereocenters, giving it a rigid 3D conformation crucial for binding to the bacterial 30S ribosomal subunit
#Tigecycline
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