Transmembrane protein | Transmembrane region in Protein sequence | TMHMM

Описание: A transmembrane protein (TP), also known as intact protein, is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequently undergo significant conformational changes to move a substance through the membrane. They are usually highly hydrophobic and aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta-barrels) can be also extracted using denaturing agents.
Transmembrane proteins play an important role in molecular transport, signal transduction, energy utilization and other basic physiological processes.
For example, many natural transmembrane proteins act as channels for specific substances to pass through the biofilm, and some transmembrane proteins receive or transmit cellular signals. The strong attachment of the transmembrane protein to the biofilm is due to the hydrophobic interaction of the membrane lipid with the hydrophobic region of the protein.
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