SNRI Antidepressants: Pharmacology Made Easy & Clinically Relevant

Описание: In this This Is Why pharmacology review, Dr. Busti unpacks the Serotonin–Norepinephrine Reuptake Inhibitors (SNRI) — how they evolved as “cleaner, safer TCA-like” options and why they’re often the next step after SSRIs for major depressive disorder and anxiety disorders. Dr. Busti compares the class head-to-head and zooms into real-world decisions: when SNRIs shine (e.g., pain comorbidities), when to be cautious (e.g., hypertension, SIADH/hyponatremia, discontinuation syndrome), and how dose and kinetics shape outcomes (e.g., venlafaxine as SSRI at low dose, true SNRI at higher doses).

You’ll get crisp pearls on the key agents—duloxetine, venlafaxine, desvenlafaxine, milnacipran, levomilnacipran—including indications beyond MDD (GAD, panic/social anxiety, neuropathic pain, fibromyalgia, chronic MSK pain; regional use in stress urinary incontinence), common adverse effects, interaction traps (e.g., MAOI washouts, serotonergic stacking), and a practical monitoring & counseling checklist you can use tomorrow.

👉 Companion tables (indications, mechanisms, PK/PD, side-effect grid, and monitoring prompts) are available for download and teaching at https://www.thisiswhy.health/topics/p...

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Chapter Table of Contents
00:00 Introduction to SNRIs: Serotonin–Norepinephrine Reuptake Inhibitors
02:44 SNRI Clinical Indications: MDD, GAD, Fibromyalgia, Chronic Pain & Other Approved Uses
03:08 SNRI Drug Lineup: Venlafaxine, Desvenlafaxine, Milnacipran, Levomilnacipran
04:01 Mechanism of Action: Reuptake Inhibition & CNS Pathways
10:24 Side Effects: Serotonergic Effects, Sympathomimetic Effects & CNS Activation
20:10 Pharmacokinetics & Metabolism: CYP Pathways, Substrates, Inhibitors & Drug Interactions
21:44 Class-Wide Side Effect Comparison: GI, Insomnia, Hemodynamic Effects & Tolerability
22:35 Clinical Pearls: Energy Effects, Selectivity, and Choosing the Right SNRI

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#SNRI #SNRIantidepressants #pharmacology #PsychiatryPharmacology #medicaleducation

Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.