What Happens When CRISPR Backfires?

Описание: CRISPR is touted as a gene editing technology to change the world, but recent studies show that it might actually be doing more harm than good.

Your Body Could Be Immune to CRISPR! Is This the End of Gene Editing? -    • Your Body Could Be Immune to CRISPR! Is Th...  

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CRISPR gene editing is not quite as precise and as safe as thought
https://www.newscientist.com/article/...
“But in studies of mice and human cells, Bradley’s team has found that in around a fifth of cells, CRISPR causes deletions or rearrangements more than 100 DNA letters long. These surprising changes are sometimes thousands of letters long.”

Doctors In China Lead Race To Treat Cancer By Editing Genes
https://www.npr.org/sections/health-s...
“Now he's back at the hospital to get an experimental treatment. It involves using cells from his own immune system, known as T cells, after they have been taken out of his body and genetically altered in a lab by the gene-editing tool called CRISPR.”

2 new CRISPR tools overcome the scariest parts of gene editing
https://www.vox.com/2017/10/25/165273...
“With CRISPR/Cas9, the changes to the genome, or the cell’s recipe book, are permanent. You can’t undo them. With REPAIR, since researchers can target single bits of ephemeral RNA, the changes they make are transient, even reversible.”

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