OVERCOMING DOWNSTREAM BOTTLENECKS IN THE UPSCALING PROCESS
Автор: Biopharma Webinar Series
Загружено: 2022-01-18
Просмотров: 231
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Presented by Dr. Dakshesh Mehta, Associate Vice President and Head of Bioprocess Group at Biotech & Genomics division, Wockhardt Research Center.
In recent years, due to major advances in upstream processes, therapeutic proteins can be produced at higher concentrations than ever before. For, these high-titer, high-cell density production, chromatography operations may be perceived bottlenecks. Column size limitations, low dynamic capacity and buffer volume requirements are generally considered as contributing factors, apart from high resin costs. The talk will cover how flexible manufacturing systems could help establish efficient downstream processes to overcome capacity bottlenecks. Also how downstream footprint can be reduced whilst speeding up purification process. Is there anyway, one could eliminate chromatography operations with other technologies that may require less space
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