How do GnRH Analogues works? | Zoladex | Prostap | Other GnRH Analogues

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GnRH agonists work by desensitizing the stimulatory effect of GnRH on the pituitary gland which secretes reproductive hormones in response. GnRH agonist is a synthetic form of the natural GnRH secreted by the hypothalamus.

How do GnRH analogues work in fibroids?

Taking gonadotropin-releasing hormone agonists (GnRH-a) puts your body into a state like menopause for as long as you take it. This shrinks fibroids. After you stop taking it, your fibroids may grow back. Taking GnRH-a can cause serious side effects, such as bone loss.

What is the mechanism of action of GnRH?

Prolonged activation of GnRH receptors by GnRH leads to desensitization and consequently to suppressed gonadotrophin secretion. This is the primary mechanism of action of agonistic GnRH analogues.

How do GnRH analogues work for endometriosis?

Background and Objective: Gonadotropin-releasing hormone (GnRH) analogues, including both agonists and antagonists, are a second line therapy for treating endometriosis. They work by down-regulating the hypothalamic-pituitary-gonadal axis, suppressing ovulation and reducing estrogen levels.

What does a GnRH analogue do when given to a woman?

GnRH analogues are designed to 'turn off' the ovaries temporarily and create a temporary 'menopausal' state. This is done by blocking the hormones that stimulate the ovaries. This results in a low level of the female hormone oestrogen, which will go back to normal when the treatment is stopped.

How do GnRH agonists shrink fibroids?

One mechanism by which GnRH agonists are thought to produce a marked reduction in fibroid volume consists of decreased expression of nuclear factor of activated T cells 5 (NFAT5) (which is a hyperosmolarity gene) ‐ an action that has the effect of causing water to flow out of fibroid cells (McCarthy‐Keith 2011)