MALDI-MS for Visualizing Amyloid Deposits in the Brain | Protocol Preview

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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry - a 2 minute Preview of the Experimental Protocol

Masaya Ikegawa, Takashi Nirasawa, Nobuto Kakuda, Tomohiro Miyasaka, Yuki Kuzuhara, Shigeo Murayama, Yasuo Ihara
Doshisha University, Department of Life and Medical Systems; Bruker Daltonics K.K.,; Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, The Brain Bank for Aging Research; Doshisha University, Graduate School of Brain Science;

Molecular imaging with matrix-assisted laser desorption/ionization-based imaging mass spectrometry (MALDI-IMS) allows the simultaneous mapping of multiple analytes in biological samples. Here, we present a protocol for the detection and visualization of amyloid β protein on brain tissues of Alzheimer's disease and cerebral amyloid angiopathy samples using MALDI-IMS.

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