Neural Circuit Models of Psychedelics (Doss et al., 2022)

Описание: I. Introduction to Psychedelic Action Models
Psychedelics like psilocybin alter human perception.
They activate 5-HT2A receptors, primarily in the cortex.
Three main models explain how this alters neural circuits.
Understanding these circuits maximizes therapeutic efficacy.
It also minimizes harm while revealing novel brain functions.

II. The Cortico-Striatal Thalamo-Cortical Model
The CSTC model focuses on disrupted thalamic sensory gating.
Psychedelics directly modulate cortex, striatum, and thalamus.
This causes aberrant thalamocortical coupling and gating issues.
The cortex becomes inundated with unfiltered sensory input.
This leads to perceptual alterations and poor attention span.

III. The Relaxed Beliefs Under Psychedelics Model
The REBUS model asserts psychedelics reduce top-down control.
Higher-level networks lose control over lower brain systems.
This specifically impacts the default mode network.
The disruption breaks down typical predictive coding mechanisms.
Brain entropy and cortical network complexity thereby increase.
This state may allow for the updating of prior held beliefs.

IV. The Cortico-Claustro-Cortical Model
The CCC model is a new framework built around the claustrum.
The claustrum coordinates the recruitment of cortical networks.
Psychedelics disrupt 5-HT2A network coupling in this region.
This decouples prefrontal activity from claustral activity.
It leads to broad disruption of canonical network brain states.
This disruption explains the profound loss of cognitive control.

V. Additional Resource Support
See NourishED RFI's NotebookLM Resource Support Page.
https://notebooklm.google.com/noteboo...

VI. Source
Doss, M. K., Madden, M. B., Gaddis, A., Nebel, M. B., Griffiths, R. R., Mathur, B. N., & Barrett, F. S. (2022). Models of Psychedelic Drug Action: Modulation of Cortical-Subcortical Circuits. Brain, 145(2), 441-456.

Disclaimer: AI-generated content reviewed by a PhD researcher with a PhD in Biomedical Science & neuroscience (Brenna Bray, PhD).

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