4. Necroptosis And Pyroptosis : USMLE Step 1

Описание: 📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash  
📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash

Necroptosis and Pyroptosis

Necroptosis and Pyroptosis are two forms of programmed cell death that differ from the traditional apoptosis pathway, playing significant roles in the body's defense mechanisms against infections and in inflammatory responses. Necroptosis is a type of cell death that mimics necrosis but is regulated by specific signaling pathways. Triggered by factors like TNF-alpha, it involves the formation of a complex including RIPK1, RIPK3, and MLKL proteins, leading to cell membrane rupture and release of cell contents, often triggering inflammation. Pyroptosis, on the other hand, is an inflammatory form of programmed cell death primarily triggered by infections. It is characterized by the activation of caspase-1 or caspase-11 in mice (caspase-4 and caspase-5 in humans), which leads to the cleavage of gasdermin D, forming pores in the cell membrane and causing cell lysis. Pyroptosis plays a crucial role in the immune response by eliminating infected cells and releasing inflammatory signals to recruit immune cells.

Necroptosis:
_____________
Regulated necrosis-like cell death
Involves RIPK1, RIPK3, and MLKL proteins
Leads to inflammation through membrane rupture
Triggered by factors like TNF-alpha

Pyroptosis:
___________
Inflammatory form of programmed cell death
Triggered by infections
Involves caspase-1, caspase-4, caspase-5, and gasdermin D
Results in cell lysis and release of inflammatory signals
Both necroptosis and pyroptosis highlight the body's intricate methods for controlling cell fate in response to stress and infection, emphasizing their roles in immunity and inflammation.

#Necroptosis #Pyroptosis #CellDeath #Inflammation #Immunology #MBBS #MedicalStudents #BoardExamPrep #InfectiousDiseases #FutureDoctors #MedScience #fmge #fmgevideos #rapidrevisionfmge #fmgejan2023 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2023 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #pathologyvideos #usmlepathology