Testing for BCR::ABL kinase mutations in CML and how they impact TKi resistance
Автор: VJHemOnc – Video Journal of Hematology & HemOnc
Загружено: 2024-02-05
Просмотров: 454
Описание:
Simona Soverini, PhD, University of Bologna, Bologna, Italy, highlights the importance of testing for BCR::ABL kinase mutations in chronic myeloid leukemia (CML) and discusses how they impact resistance to tyrosine kinase inhibitors (TKis). She mentions traditional single-cell sequencing methods of mutational testing, as well as more developed next-generation sequencing (NGS) and digital polymerase chain reaction (PCR). Guidelines for how to conduct mutational testing can be found in the European LeukemiaNet manuscript. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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