Interrogate the Functions of FMRP in Brain Development Using Stem Cells

Описание: This virtual seminar series addresses a wide range of current topics in Fragile X research. Hosted by FRAXA and organized by Michael Tranfaglia, MD and Patricia Cogram, PhD, sessions feature outstanding speakers from universities and the biotech and pharmaceutical industries.

---- Presentation Abstract ----
During the past 15 years, Dr. Xinyu Zhao’s group has used both mouse and human neural stem cells to interrogate the functions of FMRP in brain development. They have discovered that a lack of FMRP leads to altered neural stem cell self-renewal, neural differentiation, and neuronal maturation. They have shown that FMRP-deficiency results in mitochondrial deficits. Using a combination of CRISPR gene editing, genome-wide target identification transcriptomics, cellular imaging, and behavioral techniques, they have identified novel molecular and signaling pathways underlying these deficits in both mouse and human models and discovered potential treatment targets for fragile X syndrome.

---- Speakers ----
Xinyu Zhao, PhD
Jenni and Kyle Professor, Waisman Center and Department of Neuroscience at University of Wisconsin-Madison

---- Timestamps ----
0:00 Intro with Dr. Michael Tranfaglia
3:39 Interrogate the Functions of FMRP in Brain Development Using Stem Cells
54:10 Questions and Answers
1:26:37 Closing remarks

---- About FRAXA ----
FRAXA’s mission is to find effective treatments and ultimately a cure for Fragile X syndrome. We directly fund research grants and fellowships at top universities around the world. We partner with biomedical and pharmaceutical companies, large and small, to bridge the gap between research discoveries and actual treatments.

Treatments for Fragile X are likely to help people affected by autism, Alzheimer’s, and other brain disorders.

To learn more about FRAXA's Fragile X syndrome research, to get involved with Fragile X awareness and events or to donate to FRAXA research, visit www.fraxa.org

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