CCDG 2016 11 Paula Hong Strategies to Address the Impact of Instrument Design Characteristics
Автор: CCDG Channel
Загружено: 2016-11-29
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Methods Transfer Review: Strategies to Address the Impact of Instrument Design Characteristics
Paula Hong, PhD
Principal Scientist
Waters Corporation
Transfer of established reversed phase methods across both HPLC and UHPLC chromatographic platforms requires careful consideration of the operating parameters and design of each instrument. To illustrate these affects, system characteristics, including dwell volume, gradient formation, extra-column dispersion and linearity will be reviewed and related to the differences in the resulting chromatography. Different instrument configurations will also be evaluated and discussed, including quaternary and binary pumps as well as flow through and off-line injection modes. Based on the effects of individual system characteristics, strategies for successful methods transfer will be described. In these examples, consideration is made to conduct method transfer in accordance with regulatory guidelines for allowable adjustments to compendial methods.
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