I F'ed Up and Got Called Out! | Educational Video | Biolayne

Описание: In my education video last week I discussed a meta-analysis on lean beef & CVD risk factors but the graphic & citation I posted were from a different paper, a Bayesian network meta-analysis on red meat & the authors of the paper called me out

Oof. Embarrassing

It was an honest mistake on my part, but still boneheaded nonetheless & I deserved to get called out. You all trust me to give you accurate information & I screwed up. I’m here to take my lumps. So let’s talk about these 2 studies

The study on beef I actually did a breakdown on last time (PMID: 39649475):

1️⃣ Beef-Specific Meta-Analysis (Pairwise RCT Meta)
– Focused mostly on lean beef
– Isocaloric substitution trials
– Directly compared beef to poultry, fish, plant proteins
– LDL difference: ~+0.02 mmol/L (~1 mg/dL) → basically neutral

2️⃣ Red Meat Network Meta-Analysis (Bayesian) (PMID: 40997609). Network meta-analysis do not require direct comparisons in order to approximate differences between treatments. They just need same/similar comparator groups. For example if red meat gets compared to fish in one study, & in another study plant protein gets compared to fish, you can then approximate a comparison of red meat to plant protein with those studies since they share a similar comparators

This study:
– Included broader red meat (beef, pork, lamb)
– Combined direct + indirect comparisons
– Ranked protein sources
– Red meat vs plant protein: ~+0.19 mmol/L (~7 mg/dL) LDL
– Red meat vs fish: ~+0.07 mmol/L (~3 mg/dL)

Important nuance:
When red meat was lean & saturated fat was low, LDL differences were small

My take home is that both plant & animal proteins can be part of a healthy diet. For animal proteins focus on lean meats, limit saturated fat & calories, & be sure to get in enough fiber (more than 25g/day), & focus on mono & polyunsaturated sources of fat

Take home:
• Lean beef in controlled diets ≠ dramatic LDL spike
• Plant protein diets produce lower LDL (likely due to fiber, PUFA, & polyphenol compounds in sources of plant protein)
• Saturated fat, calorie intake, & dietary context matter

Appreciate the authors calling me out

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