Positive Gene Regulation and Negative Gene Regulation | Molecular Basis of Inheritance |

Описание: Positive Gene Regulation and Negative Gene Regulation | Molecular Basis of Inheritance | Class12th | Part 38 | #NEET |#CBSE | #Concept | #positivegeneregulation | #negativegeneregulation | #generegulation | #lacoperon | #transcription | #translation| #regulatorgene | #betagalactosidase | #operatorsite | #permease | #induciblegene | #transacetylase | #structuralgene |


Negative Gene Regulation:
Negative gene regulation involves the inhibition of gene expression by regulatory proteins known as repressors.

Mechanism:
In negative regulation, a repressor protein binds to an operator sequence in the DNA, which is located near or within the promoter region of a gene or operon.
When the repressor is bound to the operator, it prevents RNA polymerase from binding to the promoter or proceeding with transcription, thus blocking the expression of the downstream genes.
Example:
The lac operon in E. coli is a classic example of negative gene regulation. In the absence of lactose, the lac repressor binds to the operator, preventing transcription of the lac genes. When lactose is present, it binds to the repressor, causing it to release from the operator and allowing transcription to proceed.
Positive Gene Regulation:
Positive gene regulation involves the activation of gene expression by regulatory proteins known as activators.

Mechanism:
In positive regulation, an activator protein binds to a specific DNA sequence (often near the promoter) and enhances the binding or activity of RNA polymerase at the promoter.
This binding increases the rate of transcription, leading to higher levels of gene expression.
Example:
The catabolite activator protein (CAP) in the lac operon is an example of positive gene regulation. When glucose levels are low, cAMP levels increase, and cAMP binds to CAP. The CAP-cAMP complex then binds to a specific site near the lac promoter, enhancing the binding of RNA polymerase and promoting transcription of the lac operon genes.






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This video includes :-
-- Molecular Basis of Inheritance Part 38
-- Negative gene regulation
-- positive gene regulation



✔ Time Stamps :-
00:00 Molecular Basis of Inheritance Part 38
01:15 Negative gene regulation
05:15 positive gene regulation







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