Stem Cells Regenerate the Body’s Tissues

Описание: Dr, Katsaros talks about how stem cells derived from liposuction are useful not just in cosmetic surgery, but in the treatment of osteoarthritis and other inflammatory conditions.
When we perform liposuction, we actually harvest a clumpy mixture of fat cells as well as other specialized cells which are closely adherent to to each other and form a lumpy mixture which is called the lipoaspirate.
The initial lipoaspirate is not clinically useful, because it has a lumpy consistency, similar to chili, and because useful cells are adherent to non-useful waste products that we don’t need.
If all we’re doing is liposuction only, the lipoaspirate is treated as waste and discarded.
However, as described in this video, the lipoaspirate can be processed to yield three very useful layers. The fat layer, the stromal vascular layer or fraction and the soluble layer.
The fat layer can be harvested and processed and micronized into macrofat globules of about 2.4 mm which is ideal for fat transfer to the breast and buttock
Fat can be micronized further to microfat, or even nano fat.
Microfat is micronized to 1.2 mm which is ideal for fat transfer to the face such as the cheeks, temples, and earlobes. It can also be used for volume replacement of the hands.
Microfat can be micronized to nanofat, which is less than 1.2mm. We micronize nanofat to .04 mm for nanofat injections to the hollow above the eyes, as a lip filler or for filling very fine wrinkles.
The lowest layer, or fraction, is called the Stromal vascular Fraction or SVF. It contains:
Mesenchymal stem cells which are regenerative cells, They facilitate tissue regeneration by differentiating into local cell types and secreting growth factors and cytokines.
Mesenchymal stem cells themselves do not add a lot of volume-fat cells do that. However mixing fat cells with SVF as well as the soluble fraction, which contains many growth factors, increases the survival rate of fat cells.
One clinical trial found SVF-enriched fat had a survival rate of 77.6% (±11.6%) versus 56.2% (±9.5%) for standard fat grafting at 6 months, demonstrating a robust advantage for mixing fat with SVF usage.
The SVF has other useful cells including:
Fibroblasts that produce collagen which improves elasticity and strength of facial skin.

SVF also contains immune cells such as T-cells and macrophages which are important in immune modulation
Since cells from the stromal vascular fraction include stem cells and anti-inflammatory cells, it help her osteoarthritic joints and other inflammatory conditions.
Clinical data support improved quality of life and reduced need for surgical intervention in patients with moderate to severe osteoarthritis.
SVF has shown efficacy in the treatment of chronic wounds, burns, aged skin, and scars.
Its angiogenic and pro-reparative effects accelerate wound closure, granulation, and neovascularization.
Clinical research is ongoing for SVF-based therapy in hair restoration, where it is thought to support hair follicle regeneration.
It is important to note that Medicare and private insurance companies do not cover SVF at this time because they consider the treatment experimental.