A Multi-Omics Approach to Understanding the Role of Proteases in Swine Dysentery - Sraddha Uppili
Автор: SU Research Symposium
Загружено: 2025-11-17
Просмотров: 37
Описание: Brachyspira hyodysenteriae is a Gram-negative spirochete bacterium that colonizes the colon, causing diarrheic mucohemorrhagic colitis (swine dysentery) in post-weaning pigs. While clinical symptoms are well characterized, the host-pathogen interactions remain elusive. Protease overactivity has been proposed as a hallmark of colitis; however, specific protease dysregulation has never been addressed in swine dysentery. My research aimed to characterize the proteolytic balance in the colon during swine dysentery in controlled experiments challenging weaned pigs with B. hyodysenteriae. Specifically, I integrated clinical symptoms of swine dysentery and colitis pathology with the molecular protease profiles using bioinformatics approaches. The hypothesis is that increased protease activity contributes colitis damage and bloody diarrhea during swine dysentery. The purpose of conducting this research is to provide mechanistic insights into swine dysentery pathogenesis to drive the development of novel therapeutic strategies to improve swine health and welfare.
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