Modifying genomes - Patrick David Hsu, Principal Investigator at Salk Institute

Описание: Rapid advances in DNA sequencing technologies over the past decade have transformed our ability to read the genome, epigenome, and transcriptome of all living organisms, illuminating the genetic building blocks and dynamics of biological systems. However, establishing causal linkages between genetic changes to cellular function requires the ability to control or modulate endogenous genetic sequences or epigenetic states.

Hsu's team is developing and applying novel technologies that make it possible to systematically reverse-engineer cellular processes through rapid and precise perturbations. The group draws upon diverse approaches from synthetic biology, genomics, and neuroscience for the high-throughput interrogation and control of transcriptional and epigenetic cell states. The goal is to uncover the biological mechanisms behind neurodegenerative disease and complex genetic disorders, as well as to develop tools and therapeutic strategies for their treatment.