Target Your Molecular Vulnerabilities with Personalized Cancer Treatment Vamadevan and Christoffer

Описание: September 3, 2025 CancerPatient Lab Session 159
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Full transcript: docs.google.com/document/d/1uQ9trh74ixB257rYJWAMyuZGDaVqVQBvHFdTefPfbWg/edit?usp=sharing

“We want to make precision oncology equitable. We want to make it scalable. And we want to make it as impactful as we can today, across the globe. We don't want to wait for future drugs or future technologies. Those will come, and those will be absolutely vital. The patients I'm seeing are getting younger and younger. We're not talking about, or we shouldn't be talking about, 5-year survival anymore. We need to be talking about 20-year survival. The opportunity and the data that we have at our fingertips gives us a massive opportunity, a massive public health opportunity, to scale precision oncology right now.” – Padman Vamadevan, MD

“When I look at the healthcare system within this realm of oncology, what you notice is a vast underutilization of the Pharmacopeia (the list of drugs and the ways they can be used). It comes to pharmacology, where, on average, these small molecules affect a dozen relevant cellular pathways, but due to financial reasons, they will never get FDA approval… It's a systemic failure in the system the way the system is structured. It’s the same thing with these genomic reports, which are vastly underutilized.” – Travis Christofferson

Meeting Summary
Many advanced cancer patients and their loved ones seek more than the "standard of care" - the generally accepted testing and treatment guidelines. They want personalized, evidence-based treatment plans that reflect the unique biology of their cancer, their values, and their goals. They may be exploring beyond conventional protocols but lack the scientific expertise or time to evaluate which interventions are best evidenced to target the potential drivers of their disease or what these drivers could potentially be. There is a huge amount of scientific research available, but very little of it is applied to individual patients. With 100,000s of cancer research papers published, it is impossible for any doctor to keep up, no matter how experienced, much less a patient or caregiver.

Padman Vamadevan, MD, and Travis Christofferson, MS, are uniquely qualified to lead a conversation about personalizing treatment plans to an individual patient. Padman is Co-Founder and Chief Medical Officer at Astron Health, and Travis is Chief Scientific Officer. Astron Health acts as a personal cancer research team, using advanced bioinformatics, bespoke machine learning, and best-in-class scientific experts to make sense of this research and apply it to each patient’s case. Padman Vamadevan read for a degree in Natural Sciences from Queens’ College, Cambridge, then obtained his medical degree from King’s College, London, and subsequently trained in Academic Clinical Pharmacology. Over the past decade, he has focused on streamlining pathways to personalized cancer treatments by integrating cutting-edge molecular approaches at the intersection of Clinical Pharmacology, Metabolic Oncology, and Precision Theranostics. Dr Vamadevan leverages complex molecular data and the latest peer-reviewed research to develop precision therapies that target each patient’s unique cancer profile. Travis Christofferson is a leading figure and thought leader in modern oncology and the author of "Curable, Ketones: The Fourth Fuel", and "Tripping Over the Truth". He earned a bachelor's degree in molecular biology from Montana State University's Honors College and a master's in material engineering and science from the South Dakota School of Mines and Technology. As a former full-time science writer and founder of the Foundation for Metabolic Cancer Therapies, Travis brings extensive expertise to Astron's research initiatives.

Discussion topics:
Personalizing your cancer treatment can be better than following the "standard of care"

Key tests to enable personalized treatment

Translating your data into a personalized treatment strategy

Can you use ChatGPT or other AI engines for finding promising treatments?

Other AI tools may not have the specificity and guardrails required to flag safe and well-evidenced interventions specific to your case.

Keep ing.current with the latest research

Accessing personalized cancer treatment services

Learn more about personalizing your cancer treatment -    / @cancerpatientlab  

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