Pro-clotting Mechanisms - Thromboxane A2, Endothelin - Coagulation - Hematology

Описание: Pro-clotting Mechanisms - Thromboxane A2, Endothelin - Coagulation - Hematology.

Blood coagulation is the most important decision in your body...Too much coagulation and you form an unwanted clot (such as myocardial infarction, DVT/PE or a stroke)...Too little coagulation and you may bleed to death.

That's why blood clotting/coagulation is balanced by anti-clotting mechanisms VS pro-clotting mechanisms counteracting each other.

In the previous video of this series, I have discussed the anti-clotting mechanisms (such as heparin, heparan sulfate, prostacyclin,...etc):    • Anti-clotting Mechanisms - Heparin, Warfar...  

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Primary hemostasis is balanced on the dynamic harmonious antagonism between the smooth endothelium (that prefers laminar blood flow) and thrombocytes (which favor clotting and thrombosis).

Platelets are called thrombocytes "cells of thrombus".

The smooth endothelium is squamous epithelium that lines the blood and lymphatic vessels from the inside.

When platelets roll over the smooth endothelium, nothing happens.
But, once there is an injured endothelium, platelets adhere, activate and aggregate to form a temporary platelet plug (primary hemostasis).
Then, the coagulation factors are stimulated "thanks to subendothelial collagen, tissue thromboplastin and platelet factor 3), coagulation cascade ensues until fibrinogen is converted into fibrin fibers trapping the RBCs and forming a stronger thrombus (secondary hemostasis).

After that, fibrinolysis occur (thanks to tissue plasminogen activator or tPA) to destroy the clot and restore function and flow.

Hemostasis is defined as “cessation of blood bleeding”.

There are 2 types of hemostasis:
1. Primary hemostasis: formation of weak, temporary platelet plug (by platelets).
2. Secondary hemostasis: formation of stronger fibrin meshwork (by coagulation factors).

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To be able to answer exam questions, Try to think of primary hemostasis and secondary hemostasis as two separate entities. 1ry hemostasis involves platelets and 2ry hemostasis involves the coagulation cascade. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
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