Dabrafenib, trametinib & neoadjuvant pembrolizumab in anaplastic thyroid cancer
Автор: VJOncology
Загружено: 2025-06-01
Просмотров: 199
Описание:
Mark Zafereo, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses a Phase II trial of neoadjuvant pembrolizumab with dabrafenib and trametinib (DTP) in patients with BRAF V600E–mutated anaplastic thyroid cancer. This approach enabled a high rate of complete or near-complete resections, with many patients achieving a complete pathologic response. Progression-free and overall survival outcomes were improved compared to historical controls. Safety was manageable, though serious adverse events occurred. These results support DTP as a new standard of care in this setting. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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